Visible‐Light‐Induced Domino Cyclization to Access Pyrido[2,3‐d]pyrimidine‐2,4‐diones via a Radical‐Polar Crossover Reaction

Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical‐polar crossover (RPC)‐enabled three‐component cyclization of bromodifluoroalkyls with enaminones and 6‐aminouraciles via a visible‐light‐induced domino...

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Bibliographic Details
Published in:Chinese journal of chemistry 2024-10, Vol.42 (19), p.2346-2350
Main Authors: Zuo, Wanqing, Cheng, Yu, Zhu, Zhizhen, Zuo, Lingling, Geng, Xiao, Li, Zhifang, Wang, Lei
Format: Article
Language:English
Subjects:
6‐Aminouraciles
Bromodifluoroalkyls
Enaminones
Heterocycles
Photocatalysis
Radicals
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Summary:Comprehensive Summary Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now report a radical‐polar crossover (RPC)‐enabled three‐component cyclization of bromodifluoroalkyls with enaminones and 6‐aminouraciles via a visible‐light‐induced domino cyclization. The reaction exhibited a broad substrate scope (> 40 examples) including complex molecules, which highlighted the utility of this strategy for the construction of a library of bioactive analogs. A radical‐polar crossover (RPC)‐enabled three‐component cyclization of bromodifluoroalkyls with enaminones and 6‐aminouraciles via a visible‐light‐induced domino strategy was developed.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202400315