Topical application of oxifulvic acid suppresses the cutaneous immune response in mice

The antiinflammatory activity of topically applied coal‐derived fulvic acids (called oxifulvic acid) at 4.5% and 9% was compared with that of diclofene sodium at 1% and betamethasone at 0.1% in a murine model of contact hypersensitivity. Mice were sensitised with dinitrofluorobenzene and challenged...

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Bibliographic Details
Published in:Drug development research 2001-05, Vol.53 (1), p.29-32
Main Authors: Van Rensburg, Constance E.J., Malfeld, Susan C.K., Dekker, Johan
Format: Article
Language:English
Subjects:
betamethasone
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
diclofene sodium
Medical sciences
mice
oxifuvic acid
Pharmacology. Drug treatments
topical antiinflammatory
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Summary:The antiinflammatory activity of topically applied coal‐derived fulvic acids (called oxifulvic acid) at 4.5% and 9% was compared with that of diclofene sodium at 1% and betamethasone at 0.1% in a murine model of contact hypersensitivity. Mice were sensitised with dinitrofluorobenzene and challenged 6 days later by application to the dorsal surface of the right ear. The inflamed ears of the mice were then treated topically, and the thickness of the ears was measured daily. Oxifulvic acid at both concentrations compared favourably with both diclofene sodium and betamethasone in suppressing the cutaneous inflammatory response. Oxifulvic acid possesses antiinflammatory properties and may be of clinical benefit in the treatment of inflammatory skin conditions in humans. Drug Dev. Res. 53:29–32, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.1166