Platinum-Group Chelate Complexes with 9-Hydroxyphenalenone Derivatives: Synthesis, Structures, Spectroscopic Properties and Cytotoxic Activities

The following platinum‐group chelate complexes with 5‐R‐9‐hydroxyphenalenone (L1: R = H; L2: R = Me; L3: R = Pr) have been prepared: [RhI(L)(CO)2] (1a: L = L1; 1b: L = L2; 1c: L = L3), [PdII(L)2] (2a: L = L2; 2b: L = L3), [PtII(L1)(NH3)2](NO3) (3), and (Bu4N)[PtII(L1)(Cl)2] (4). Compounds 1a and 1b...

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Bibliographic Details
Published in:European Journal of Inorganic Chemistry 2006-02, Vol.2006 (3), p.558-565
Main Authors: Mochida, Tomoyuki, Torigoe, Reiko, Koinuma, Takeo, Asano, Chika, Satou, Tadaaki, Koike, Kazuo, Nikaido, Tamotsu
Format: Article
Language:English
Subjects:
Metal-metal interactions
O ligands
Palladium
Platinum
Rhodium
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Summary:The following platinum‐group chelate complexes with 5‐R‐9‐hydroxyphenalenone (L1: R = H; L2: R = Me; L3: R = Pr) have been prepared: [RhI(L)(CO)2] (1a: L = L1; 1b: L = L2; 1c: L = L3), [PdII(L)2] (2a: L = L2; 2b: L = L3), [PtII(L1)(NH3)2](NO3) (3), and (Bu4N)[PtII(L1)(Cl)2] (4). Compounds 1a and 1b are different colors in the solid state: yellow and deep red, respectively. X‐ray analysis revealed that 1a has a regular π–π stacking structure while 1b has a dimer‐like arrangement with a RhI–RhI distance of 3.2336(6) Å. Both solids were luminescent at 77 K. Compounds 2a and 2b are planar extended π‐conjugated complexes, which exhibit two‐dimensional stacking modes in the crystal. The solid‐state structure of complex 3 is hydrogen‐bonded in a polar arrangement. The cytotoxic activities of 1a, 3, and 4, evaluated in vitro against HL60 human acute myeloid leukemia cell lines, were comparable to that of cisplatin. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.200500778