Front Cover: From Cyclic Ketimines to α‐Substituted Cyclic Amino Acids and their Derivatives: Influence of Ring Size and Substituents on Stability and Reactivity of Cyclic Aminonitriles (Eur. J. Org. Chem. 4/2019)

• Published in: European journal of organic chemistry 2019-01, Vol.2019 (4), p.611-611
• Main Authors: Voznesenskaia, Natalia G., Shmatova, Olga. I., Sosnova, Anna A., Nenajdenko, Valentine G.
• Format: Article
• Language: English
• ISSN: 1434-193X; 1099-0690
• DOI: 10.1002/ejoc.201900053

The Front Cover shows an insertion of a block which represents a variety of derivatives of natural cyclic amino acids, such as proline and pipecolic acid. Incorporation of synthetically modified amino acids instead of their natural analogs in different biological objects and peptides can improve their properties, for example, metabolic stability and biological activity. The variation of the substituent in alpha‐position and ring size in a cyclic amino acid is a useful tool, which can help to develop the most appropriate compound for specific needs. A building block which is an amino acid or their derivative completes the original structure, making it stable just like a brick wall. More information can be found in the Full Paper by V. G. Nenajdenko et al.