Serum type III procollagen peptide in alcoholic liver disease and idiopathic hemochromatosis: Its relationship to hepatic fibrosis, activity of the disease and iron overload

To assess the value of type III procollagen peptide (sPIIIP) as a marker of hepatic fibrosis, sera from 73 patients with alcohol‐related liver disease and 30 patients with idiopathic hemochromatosis (IHC) were studied by a specific radioimmunoassay. sPIIIP was increased in 87% of 30 patients with ci...

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Published in:Hepatology (Baltimore, Md.) Md.), 1985-05, Vol.5 (3), p.475-479
Main Authors: Colombo, Massimo, Annoni, Giorgio, Donato, Maria Francesca, Conte, Dario, Martines, Dino, Zaramella, Maria Grazia, Bianchi, Paolo A., Piperno, Alberto, Tiribelli, Claudio
Format: Article
Language:English
Subjects:
Adult
Aged
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Female
Ferritins - blood
Hemochromatosis - blood
Hemochromatosis - pathology
Humans
Liver - pathology
Liver Cirrhosis - blood
Liver Diseases, Alcoholic - blood
Liver Diseases, Alcoholic - pathology
Male
Medical sciences
Middle Aged
Peptide Fragments - blood
Procollagen - blood
Radioimmunoassay
Toxicology
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Summary:To assess the value of type III procollagen peptide (sPIIIP) as a marker of hepatic fibrosis, sera from 73 patients with alcohol‐related liver disease and 30 patients with idiopathic hemochromatosis (IHC) were studied by a specific radioimmunoassay. sPIIIP was increased in 87% of 30 patients with cirrhosis, in 16% of 32 with steatofibrosis but in none of 11 with steatosis. There was a significant correlation with histologic hepatocellular necroinflammation (r = 0.42, p < 0.01), but not with hepatic fibrosis. sPIIP was increased in 33% of 30 patients with IHC, whether or not they had cirrhosis or fibrosis, and whatever the level of iron overload or the extent of the hepatic deterioration. IHC patients with increased levels of sPIIIP had a higher prevalence of superimposed hepatic damage than did those with normal procollagen levels (p < 0.05). Our findings, therefore, weaken the diagnostic value of sPIIIP as an index of connective tissue deposition in the liver, and suggest that, at least in alcohol‐related liver disease and IHC, hepatocellular necroinflammation influences the results.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840050322