Is the magnetic resonance imaging proton spin‐lattice relaxation time a reliable noninvasive parameter of developing liver fibrosis?

During the development of liver fibrosis in rats by an individual dose‐titrated CCl4 administration, hepatic proton spin‐lattice relaxation time (T1) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy mate...

Full description

Saved in:
Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 1988-03, Vol.8 (2), p.217-221
Main Authors: Chamuleau, Robert A. F. M., De Nie, Joris H. N. Creyghton Ineke, Moerland, Marinus A., Van der Lende, Otto R., Smidt, Jaap
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carbon Tetrachloride
Gastroenterology. Liver. Pancreas. Abdomen
Hydroxyproline - metabolism
Image Processing, Computer-Assisted
Liver - metabolism
Liver - pathology
Liver Cirrhosis, Experimental - chemically induced
Liver Cirrhosis, Experimental - diagnosis
Liver Cirrhosis, Experimental - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Magnetic Resonance Imaging - methods
Medical sciences
Other diseases. Semiology
Time Factors
Triglycerides - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:During the development of liver fibrosis in rats by an individual dose‐titrated CCl4 administration, hepatic proton spin‐lattice relaxation time (T1) has been measured in vivo every 2 weeks for 8 weeks. Liver content of collagen, triglycerides and water has been measured biochemically in biopsy material. After 4 weeks of CCl4 treatment, T1 increased signifcantly and remained at the same level, whereas liver collagen reached its maximum at 8 weeks. It is concluded that, under our experimental conditions, increased hepatic T1 represents drug‐induced edema and that hepatic T1 is not a reliable noninvasive parameter for developing liver fibrosis in vivo.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840080204