Synthesis and biological evaluation of new naphthoquinone-containing pyrrolo-thiazoles as anticancer agents

Naphthoquinones undergo 1,3‐dipolar cycloaddition with bicyclic münchnones generated from thiazolidines affording new pyrrolo‐thiazoles with a fused quinone nucleus. The products were obtained as single enantiomers in good yields. These benzo[f]thiazolo[4,3‐a]isoindole‐6,11(1H,3H)‐diones are compris...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2010-07, Vol.47 (4), p.960-966
Main Authors: Lopes, Susana M. M., Laranjo, Mafalda, Serra, Arménio C., Abrantes, Ana Margarida, Rocha Gonsalves, António M. d'A., Botelho, Maria Filomena, Beja, Ana Matos, Silva, Manuela Ramos, Pinho e Melo, Teresa M. V. D.
Format: Article
Language:English
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Summary:Naphthoquinones undergo 1,3‐dipolar cycloaddition with bicyclic münchnones generated from thiazolidines affording new pyrrolo‐thiazoles with a fused quinone nucleus. The products were obtained as single enantiomers in good yields. These benzo[f]thiazolo[4,3‐a]isoindole‐6,11(1H,3H)‐diones are comprised of four fused rings and present a very planar structure. The evaluation of their anticancer activity against melanoma A375 and colorectal adenocarcinoma WiDr human cell lines showed only moderate activity but gave insight into the modeling of new structures. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.] J. Heterocyclic Chem., (2010).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.396