Synthesis, cytotoxic activity, and thermal studies of novel N-[(1,3-diphenylpyrazol-4-yl)methyl] α-amino acids

New N‐[(1,3‐diphenylpyrazol‐4‐yl)methyl]α‐amino acids (1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT‐29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC...

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Published in:Journal of heterocyclic chemistry 2010-07, Vol.47 (4), p.850-856
Main Authors: Joksović, Milan D., Bogdanović, Gordana, Kojić, Vesna, Szécsényi, Katalin Mészáros, Leovac, Vukadin M., Jakimov, Dimitar, Trifunović, Snežana, Marković, Violeta, Joksović, Ljubinka
Format: Article
Language:English
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Summary:New N‐[(1,3‐diphenylpyrazol‐4‐yl)methyl]α‐amino acids (1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i) have been synthesized and tested in vitro for their antiproliferative activity against human myelogenous leukemia K562, colon adenocarcinoma HT‐29, cervix carcinoma HeLa, and normal fetal lung fibroblasts, MRC‐5. Compounds derived from both phenylalanine enantiomer precursors appeared to be the most active against myelogenous leukemia K562 cell lines with a high cytotoxic potential. J. Heterocyclic Chem., (2010).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.400