Cynogen bromide and ethylacetoacetate in heterocyclization: Novel synthesis of tetracyclic derivative of 3-aryl quinazolinones

In this work, tricyclic 1‐amino‐4‐(substituted phenyl)[1,2,4]triazolo[4,3‐a]quinazolin‐5(4H)‐one 3 was synthesized by treatment of 2‐hydrazinyl‐3‐(substituted phenyl)quinazolin‐4(3H)‐one 2 with cyanogen bromide, which on cyclization with ethylacetoacetate to get the targeted fused tetracyclic deriva...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2010-09, Vol.47 (5), p.1144-1147
Main Authors: Deshmukh, M. B., Patil, Suresh S., Patil, Sanjeevani S., Jadhav, Swati D.
Format: Article
Language:English
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Summary:In this work, tricyclic 1‐amino‐4‐(substituted phenyl)[1,2,4]triazolo[4,3‐a]quinazolin‐5(4H)‐one 3 was synthesized by treatment of 2‐hydrazinyl‐3‐(substituted phenyl)quinazolin‐4(3H)‐one 2 with cyanogen bromide, which on cyclization with ethylacetoacetate to get the targeted fused tetracyclic derivatives of quinazoli‐4(3H)one 4. The synthesized compounds have been characterized using IR and 1H NMR, mass spectral data together with elemental analysis. J. Heterocyclic Chem., (2010).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.440