A facile solvent-free synthesis of 1-alkyl/aralkyl-2-(1-arylsulfonyl alkyl) benzimidazoles using "TBAB" as surface catalyst

Reaction 2‐(α‐chloroalkyl)benzimidazoles 1 with aryl sulphinate sodium salt 2 under solvent‐free conditions in the presence of tetrabutylammonium bromide as surface catalyst, by simple physical grinding using mortar and pestle, gives 1H‐2‐(α‐arylsulfonylalkyl)benzimidazoles 3. The latter on treatmen...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2010-11, Vol.47 (6), p.1317-1322
Main Authors: Dubey, P. K., Prasada Reddy, P.V.V., Srinivas, K.
Format: Article
Language:English
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Summary:Reaction 2‐(α‐chloroalkyl)benzimidazoles 1 with aryl sulphinate sodium salt 2 under solvent‐free conditions in the presence of tetrabutylammonium bromide as surface catalyst, by simple physical grinding using mortar and pestle, gives 1H‐2‐(α‐arylsulfonylalkyl)benzimidazoles 3. The latter on treatment with alkylating agents under solvent‐free conditions results in 1‐alkyl/aralkyl‐2‐(α‐arylsulfonylalkyl)benzimidazoles 4. Alternatively, 4 can also be prepared directly from 1‐alkyl/aralkyl‐2‐(α‐chloroalkyl)benzimidazoles 5 by reaction with 2, which in turn could be prepared by reaction of 1 with alkylating agents under solvent‐free conditions and all these reactions are free from organic solvents including experimental procedures. J. Heterocyclic Chem., (2010).
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.450