Application of the aza‐Wittig reaction for efficient synthesis of diversely substituted benzo[f]Chromeno[2,3‐d]pyrimidine and benzo[f]chromeno[2,3‐d][1,2,4]triazolopyrimidine derivatives

An efficient synthesis of novel benzo[f]Chromeno[2,3‐d]pyrimidine and unknown benzo[f]chromeno[2,3‐d][1,2,4]triazolopyrimidine derivatives is described utilizing ethyl‐2‐amino‐4‐phenyl‐4H‐benzo[f]chromene‐3‐carboxylate as precursor via aza‐Wittig reaction. The process proved to be simple, high‐yield...

Full description

Saved in:
Bibliographic Details
Published in:Journal of heterocyclic chemistry 2024-04, Vol.61 (4), p.543-549
Main Authors: Hassan, Mohamed, Barsy, Magda A., El Rady, Eman A., Al‐Ayed, Abdullah Sulaiman, Frempong, Mona, Sadek, Kamal U.
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An efficient synthesis of novel benzo[f]Chromeno[2,3‐d]pyrimidine and unknown benzo[f]chromeno[2,3‐d][1,2,4]triazolopyrimidine derivatives is described utilizing ethyl‐2‐amino‐4‐phenyl‐4H‐benzo[f]chromene‐3‐carboxylate as precursor via aza‐Wittig reaction. The process proved to be simple, high‐yielding, and efficient. An effective iminophosphorane mediates the synthesis of a fused ring system with potent anticancer relevance via the Aza‐Wittig reaction.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.4784