1,3‐cycloaddition reactions of 2‐oxo‐2 H ‐[1]benzopyran‐4‐carbonitrile N ‐oxide. Synthesis of several new 4‐substituted coumarins

1,3‐Cycloaddition reactions of new 2‐oxo‐2 H ‐[1]benzopyran‐4‐carbonitrile N ‐oxide 2 with dipolarophiles, o ‐aminophenols and o ‐phenylenediamine resulted in 4‐heterocyclic substituted coumarin derivatives. These derivatives are screened for antiinflammatory activity in vitro through their antiprot...

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Published in:Journal of heterocyclic chemistry 1998-05, Vol.35 (3), p.619-625
Main Authors: Nicolaides, Demetrios N., Fylaktakidou, Konstantina C., Litinas, Konstantinos E., Papageorgiou, George K., Hadjipavlou‐Litina, Dimitra J.
Format: Article
Language:English
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Summary:1,3‐Cycloaddition reactions of new 2‐oxo‐2 H ‐[1]benzopyran‐4‐carbonitrile N ‐oxide 2 with dipolarophiles, o ‐aminophenols and o ‐phenylenediamine resulted in 4‐heterocyclic substituted coumarin derivatives. These derivatives are screened for antiinflammatory activity in vitro through their antiproteolytic activity, the interaction with 1,1‐diphenyl‐2‐picrylhydrazyl and the ability to affect superoxide anion and to inhibit β‐glucuronidase and soybean lipoxygenase.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570350321