Transformation of schiff bases derived from alpha-naphthaldehyde. Synthesis, spectral data and biological activity of new-3-aryl-2-(α-naphtyl)-4-thiazolidinones and N-aryl-N-[1-(α-naphthyl)but-3-enyl]amines

New N‐aryl substituted 2‐(α‐naphthyl)‐4‐thiazolidinones were prepared by the cyclocondensation of α‐mercaptoacetic acid and corresponding N‐(α‐naphthyliden)anilines. The same starting materials were utilized to obtain a new series of N‐aryl‐N‐[1‐(α‐naphthyl)but‐3‐enyl]amines, which was synthesized t...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2004-11, Vol.41 (6), p.995-999
Main Authors: Kouznetsov, Vladimir, Rodríguez, William, Stashenko, Elena, Ochoa, Carmen, Vega, Celeste, Rolón, Miriam, Pereira, David Montero, Escario, José A., Barrio, Alicia Gémez
Format: Article
Language:English
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Summary:New N‐aryl substituted 2‐(α‐naphthyl)‐4‐thiazolidinones were prepared by the cyclocondensation of α‐mercaptoacetic acid and corresponding N‐(α‐naphthyliden)anilines. The same starting materials were utilized to obtain a new series of N‐aryl‐N‐[1‐(α‐naphthyl)but‐3‐enyl]amines, which was synthesized through an addition of the Grignard reagent (allylmagnesium bromide) to the double bond CN of the aldimines. The antichagasic and trichomonacidal in vitro activity, as well as, the antifungal and cytotoxic properties of some of these compounds were evaluated.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570410624