An efficient synthesis of pyrazolo[3,4-b]pyrrolo[2,3-d]pyridines from 5-aminopyrazoles and cyclic β-keto ester

5‐Chloroethylpyrazolo[3,4‐b]pyridines were synthesized by condensation of 5‐aminopyrazoles with α‐acetyl γ‐butyrolactone followed by cyclization treating with phosphorous oxychloride. 5‐Chloroethyl‐pyrazolo[3,4‐b]pyridines, thus obtained, were then converted to the corresponded tricyclic pyrazolo[3,...

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Bibliographic Details
Published in:Journal of heterocyclic chemistry 2008-11, Vol.45 (6), p.1711-1717
Main Authors: Toche, Raghunath B., Ghotekar, Bhausaheb K., Kendre, Dhananjay B., Kazi, Muddassar A., Jachak, Madhukar N.
Format: Article
Language:English
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Summary:5‐Chloroethylpyrazolo[3,4‐b]pyridines were synthesized by condensation of 5‐aminopyrazoles with α‐acetyl γ‐butyrolactone followed by cyclization treating with phosphorous oxychloride. 5‐Chloroethyl‐pyrazolo[3,4‐b]pyridines, thus obtained, were then converted to the corresponded tricyclic pyrazolo[3,4‐b]‐pyrrolo[2,3‐d]pyridines by treating with some primary amines.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.5570450624