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Synthesis of tritium labeled isotopomers of L-tyrosine
The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymat...
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Published in: | Journal of labelled compounds & radiopharmaceuticals 2002-06, Vol.45 (7), p.559-567 |
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container_end_page | 567 |
container_issue | 7 |
container_start_page | 559 |
container_title | Journal of labelled compounds & radiopharmaceuticals |
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creator | Augustyniak, W. Suchecki, P. Jemielity, J. Kański, R. Kańska, M. |
description | The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L‐Phe have been converted into [2 ‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐, and [3S‐3H]‐L‐Tyr by using the enzyme L‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/jlcr.582 |
format | article |
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Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L‐Phe have been converted into [2 ‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐, and [3S‐3H]‐L‐Tyr by using the enzyme L‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.582</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; enzyme ; Fundamental and applied biological sciences. Psychology ; labeling ; Methods. Procedures. Technologies ; optical isotopomer ; phenylalanine ; tritium ; tyrosine</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2002-06, Vol.45 (7), p.559-567</ispartof><rights>Copyright © 2002 John Wiley & Sons, Ltd.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3312-5e928a0fdc31d15f37a7c659adc6b30e1dd21dde78eef3897b9ccd374c2cc24b3</citedby><cites>FETCH-LOGICAL-c3312-5e928a0fdc31d15f37a7c659adc6b30e1dd21dde78eef3897b9ccd374c2cc24b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13737969$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Augustyniak, W.</creatorcontrib><creatorcontrib>Suchecki, P.</creatorcontrib><creatorcontrib>Jemielity, J.</creatorcontrib><creatorcontrib>Kański, R.</creatorcontrib><creatorcontrib>Kańska, M.</creatorcontrib><title>Synthesis of tritium labeled isotopomers of L-tyrosine</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L‐Phe have been converted into [2 ‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐, and [3S‐3H]‐L‐Tyr by using the enzyme L‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd.</description><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>enzyme</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>labeling</subject><subject>Methods. Procedures. Technologies</subject><subject>optical isotopomer</subject><subject>phenylalanine</subject><subject>tritium</subject><subject>tyrosine</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp1j81KAzEYRYMoWKvgI8xGcJOav5lMllq1KoOiVroMmfxgdNopyYjO25s6RVcuPu7iHs7HBeAYowlGiJy9NTpM8pLsgBFGQkBMGdsFI0QLAlmJ6D44iPENodQxNgLFc7_qXm30MWtd1gXf-Y9l1qjaNtZkPrZdu26XNvzUFez60Ea_sodgz6km2qNtjsHL9dV8egOrh9nt9LyCmlJMYG4FKRVyRlNscO4oV1wXuVBGFzVFFhtD0lleWutoKXgttDaUM020JqymY3A6eHX6G4N1ch38UoVeYiQ3e-Vmr0x7E3oyoGsVtWpcUCvt4x9POeWiEImDA_fpG9v_65N31fRp8G55Hzv79cur8C6LpMzl4n4m55w_XlyWC0noNwg4dCU</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>Augustyniak, W.</creator><creator>Suchecki, P.</creator><creator>Jemielity, J.</creator><creator>Kański, R.</creator><creator>Kańska, M.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200206</creationdate><title>Synthesis of tritium labeled isotopomers of L-tyrosine</title><author>Augustyniak, W. ; Suchecki, P. ; Jemielity, J. ; Kański, R. ; Kańska, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3312-5e928a0fdc31d15f37a7c659adc6b30e1dd21dde78eef3897b9ccd374c2cc24b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Bioconversions. Hemisynthesis</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>enzyme</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>labeling</topic><topic>Methods. Procedures. Technologies</topic><topic>optical isotopomer</topic><topic>phenylalanine</topic><topic>tritium</topic><topic>tyrosine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Augustyniak, W.</creatorcontrib><creatorcontrib>Suchecki, P.</creatorcontrib><creatorcontrib>Jemielity, J.</creatorcontrib><creatorcontrib>Kański, R.</creatorcontrib><creatorcontrib>Kańska, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Augustyniak, W.</au><au>Suchecki, P.</au><au>Jemielity, J.</au><au>Kański, R.</au><au>Kańska, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of tritium labeled isotopomers of L-tyrosine</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>2002-06</date><risdate>2002</risdate><volume>45</volume><issue>7</issue><spage>559</spage><epage>567</epage><pages>559-567</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L‐Phe have been converted into [2 ‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐, and [3S‐3H]‐L‐Tyr by using the enzyme L‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.582</doi><tpages>9</tpages></addata></record> |
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subjects | Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology enzyme Fundamental and applied biological sciences. Psychology labeling Methods. Procedures. Technologies optical isotopomer phenylalanine tritium tyrosine |
title | Synthesis of tritium labeled isotopomers of L-tyrosine |
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