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Synthesis of tritium labeled isotopomers of L-tyrosine

The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymat...

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Published in:Journal of labelled compounds & radiopharmaceuticals 2002-06, Vol.45 (7), p.559-567
Main Authors: Augustyniak, W., Suchecki, P., Jemielity, J., Kański, R., Kańska, M.
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container_title Journal of labelled compounds & radiopharmaceuticals
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creator Augustyniak, W.
Suchecki, P.
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Kański, R.
Kańska, M.
description The synthesis of four selectively labeled isotopomers of L‐tyrosine, (L‐Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L‐phenylalanine (L‐Phe) – [2‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐ and [3S‐3H]‐ have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L‐Phe have been converted into [2 ‐3H]‐, [2′,6′‐3H2]‐, [3R‐3H]‐, and [3S‐3H]‐L‐Tyr by using the enzyme L‐phenyl‐alanine 4′‐monooxygenase. Copyright © 2002 John Wiley & Sons, Ltd.
doi_str_mv 10.1002/jlcr.582
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ispartof Journal of labelled compounds & radiopharmaceuticals, 2002-06, Vol.45 (7), p.559-567
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subjects Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
enzyme
Fundamental and applied biological sciences. Psychology
labeling
Methods. Procedures. Technologies
optical isotopomer
phenylalanine
tritium
tyrosine
title Synthesis of tritium labeled isotopomers of L-tyrosine
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