Synthesis of tritium labelled 3(R)-HETE and 3(R),18(R/S)-DiHETE through a common synthetic route

An efficient procedure for the synthesis of 3‐hydroxyoxylipins labelled with tritium on all double bond positions is reported. The synthetic scheme involves a joint route for the formation of tetraacetylenic precursors followed by stereoselective reduction of the triple bonds either with hydrogen or...

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Bibliographic Details
Published in:Journal of labelled compounds & radiopharmaceuticals 2004-01, Vol.47 (1), p.11-17
Main Authors: Groza, Natalya V., Ivanov, Igor V., Romanov, Stepan G., Shevchenko, Valery P., Myasoedov, Nikolai F., Nigam, Santosh, Myagkova, Galina I.
Format: Article
Language:English
Subjects:
18(R/S)-DiHETE
3(R)
3(R),18(R/S)‐DiHETE
3(R)-HETE
3(R)-hydroxy-oxylipins
tritium labelled fatty acids
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Summary:An efficient procedure for the synthesis of 3‐hydroxyoxylipins labelled with tritium on all double bond positions is reported. The synthetic scheme involves a joint route for the formation of tetraacetylenic precursors followed by stereoselective reduction of the triple bonds either with hydrogen or tritium. The final tritiated products were obtained with specific activities ranging from 1.65 to 1.80 Ci/mmol. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.791