Pharmacokinetics of Nasal Fentanyl

Objective: To investigate the pharmacokinetics of intranasal fentanyl in adult post‐operative female patients. Method: Patients received both intravenous and intranasal fentanyl (approximately 50 µg) in a randomised cross‐over study. Results: Pharmacokinetic data sets from 19 patients showed intrana...

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Bibliographic Details
Published in:Journal of pharmacy practice and research 2003-03, Vol.33 (1), p.59-64
Main Authors: Lim, Stephen (CB), Paech, Michael J, Sunderland, V Bruce, Roberts, Malcolm J, Banks, Samantha L, Rucklidge, Matthew WM
Format: Article
Language:English
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Summary:Objective: To investigate the pharmacokinetics of intranasal fentanyl in adult post‐operative female patients. Method: Patients received both intravenous and intranasal fentanyl (approximately 50 µg) in a randomised cross‐over study. Results: Pharmacokinetic data sets from 19 patients showed intranasal fentanyl produced plasma levels within the therapeutic range within two minutes, with median bioavailability values of 55 % (pH 6 formulation) and 71% (pH 8 formulation) . Mean peak serum concentrations were 0.33 ng/mL (pH 6) and 0.37 ng/mL (pH 8) respectively, compared with 2.33 ng/mL after intravenous fentanyl. Conclusion: We conclude that the absorption of intranasal fentanyl is rapid, the bioavailability more than half that of intravenous administration and that the formulations studied are suitable for more extensive clinical evaluation.
ISSN:1445-937X
2055-2335
DOI:10.1002/jppr200333159