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Synthesis of 5-Substituted 2-Oxazolidinethiones and Their Antagonism to Uterotropic Effect of Diethylstilbestrol
5-(4-Aminophenoxymethyl)-2-oxazolidinethiones were synthesized by the cyclization of l-(4-aminophenoxy)-3-amino-2-propanol in the presence of potassium hydroxide and carbon disulfide. This oxazolidinethione, on reaction with suitable isothiocyanates, yielded 5-[4-(substituted thiocarbamido)phenoxyme...
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Published in: | Journal of pharmaceutical sciences 1977-06, Vol.66 (6), p.887-889 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | 5-(4-Aminophenoxymethyl)-2-oxazolidinethiones were synthesized by the cyclization of l-(4-aminophenoxy)-3-amino-2-propanol in the presence of potassium hydroxide and carbon disulfide. This oxazolidinethione, on reaction with suitable isothiocyanates, yielded 5-[4-(substituted thiocarbamido)phenoxymethyl]-2-oxazolidinethiones. These compounds antagonized the uterotropic effects of diethylstilbestrol in female rats and possessed approximate LD50 values of 400–>800mg/kg. |
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ISSN: | 0022-3549 1520-6017 |
DOI: | 10.1002/jps.2600660644 |