Oxaliplatin-based hyperthermic intraperitoneal chemotherapy in primary or recurrent epithelial ovarian cancer: A pilot study of 31 patients

• Published in: Journal of surgical oncology 2011-01, Vol.103 (1), p.10-16
• Main Authors: Frenel, Jean-Sebastien, Leux, Christophe, Pouplin, Luc, Ferron, Gwenael, Berton-Rigaud, Dominique, Bourbouloux, Emmanuelle, Dravet, François, Jaffre, Isabelle, Classe, Jean-Marc
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Carcinoma - drug therapy; Carcinoma - secondary; Carcinoma - surgery; Carcinoma, Ovarian Epithelial; cytoreductive surgery; Feasibility Studies; Female; HIPEC; Humans; Hyperthermia, Induced - methods; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Neoplasms, Glandular and Epithelial - drug therapy; Neoplasms, Glandular and Epithelial - pathology; Neoplasms, Glandular and Epithelial - surgery; Organoplatinum Compounds - adverse effects; Organoplatinum Compounds - therapeutic use; ovarian carcinoma; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - pathology; Ovarian Neoplasms - surgery; Oxaliplatin; peritoneal carcinomatosis; Peritoneal Neoplasms - drug therapy; Peritoneal Neoplasms - secondary; Peritoneal Neoplasms - surgery; Pilot Projects; Retrospective Studies; Treatment Outcome
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.21732

Background The feasibility and safety of oxaliplatin‐based hyperthermic intraperitoneal chemotherapy (HIPEC) associated with cytoreductive surgery (CRS) was assessed in patients with peritoneal carcinomatosis resulting from primary advanced or relapsing epithelial ovarian cancer (EOC). Methods Thirty‐one patients received neoadjuvant platin‐based chemotherapy followed by oxaliplatin‐based HIPEC associated with CRS as consolidation of primary therapy (n = 19) or for relapsing disease (n = 12). Grade 3/4 complications were recorded according to National Cancer Institute definitions. Results Median peritoneal carcinomatosis index (PCI) was 2.7 after neoadjuvant chemotherapy. Mean duration of surgery was 352 min (range 105–614) and median hospital stay was 11 days (range 6–87). Grade 3 toxicity was observed in nine patients: five required repeat surgery, two an invasive procedure, four rehospitalization, and three a return to the ICU. No grade 4 toxicity occurred, excepted one hypokalemia. Median progression‐free survival (PFS) for primary advanced EOC was 13.2 months and 1‐year PFS was 59.3%. Median PFS for relapsing patients was 14.3 months and 1‐year PFS was 54.4%. Conclusion CRS with oxaliplatin‐based HIPEC is feasible and relatively safe in recurrent and primary EOC. HIPEC after neoadjuvant chemotherapy reduces the PCI and decreases the number of surgical procedures and morbidity. Further evaluations of this procedure are required to assess the survival benefits. J. Surg. Oncol. 2011;103:10–16. © 2010 Wiley‐Liss, Inc.