Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models

• Published in: Molecular nutrition & food research 2011-12, Vol.55 (12), p.1759-1770
• Main Authors: Meneses, Maria E., Camargo, Antonio, Perez-Martinez, Pablo, Delgado-Lista, Javier, Cruz-Teno, Cristina, Jimenez-Gomez, Yolanda, Paniagua, Juan A., Gutierrez-Mariscal, Francisco M., Tinahones, Francisco J., Vidal-Puig, Antonio, Roche, Helen M., Perez-Jimenez, Francisco, Malagon, Maria M., Lopez-Miranda, Jose
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Biological and medical sciences; Chemokine CCL2 - genetics; Chemokine CCL2 - metabolism; Diet; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Omega-3 - administration & dosage; Feeding. Feeding behavior; Female; Food industries; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - drug effects; Humans; I-kappa B Proteins - genetics; I-kappa B Proteins - metabolism; Inflammation; Inflammation - physiopathology; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Interleukin-6 - blood; Male; Metabolic syndrome; Metabolic Syndrome - physiopathology; Middle Aged; NF-KappaB Inhibitor alpha; Postprandial Period - drug effects; Postprandial state; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201100200

Scope: Dysfunctional adipose tissue may be an important trigger of molecular inflammatory pathways that cause cardiovascular diseases. Our aim was to determine whether the specific quality and quantity of dietary fat produce differential postprandial inflammatory responses in adipose tissue from metabolic syndrome (MetS) patients. Methods and results: A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to 1 of 4 diets: (i) high‐saturated fatty acid (HSFA), (ii) high‐monounsaturated fatty acid (HMUFA), (iii) low‐fat, high‐complex carbohydrate diet supplemented with n−3 polyunsaturated fatty acids (PUFA) (LFHCC n−3), and (iv) low‐fat, high‐complex carbohydrate diet supplemented with placebo (LFHCC), for 12 wk each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post‐intervention. We found that p65 gene expression is induced in adipose tissue (p=0.003) at the postprandial state. In addition, IκBα (p