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Quantitative spectroscopic imaging with in situ measurements of tissue water T 1 , T 2 , and density
The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy ( 1 H‐MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel 1 H‐MRS studies have often included measurements of water proton T 1 ,...
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Published in: | Magnetic resonance in medicine 2009-09, Vol.62 (3), p.583-590 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The use of tissue water as a concentration standard in proton magnetic resonance spectroscopy (
1
H‐MRS) of the brain requires that the water proton signal be adjusted for relaxation and partial volume effects. While single voxel
1
H‐MRS studies have often included measurements of water proton
T
1
,
T
2
, and density based on additional
1
H‐MRS acquisitions (e.g., at multiple echo or repetition times), this approach is not practical for
1
H‐MRS imaging (
1
H‐MRSI). In this report we demonstrate a method for using in situ measurements of water
T
1
,
T
2
, and density to calculate metabolite concentrations from
1
H‐MRSI data. The relaxation and density data are coregistered with the
1
H‐MRSI data and provide detailed information on the water signal appropriate to the individual subject and tissue region. We present data from both healthy subjects and a subject with brain lesions, underscoring the importance of water parameter measurements on a subject‐by‐subject and voxel‐by‐voxel basis. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc. |
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ISSN: | 0740-3194 1522-2594 |
DOI: | 10.1002/mrm.22060 |