Cover Image, Volume 53, Issue 22

Nano(hydro)gels were prepared as “smart” drug delivery systems to take advantage of the environmental conditions of tumor tissue. This image shows nanogels administered to circulate in the body and accumulate in the tumor due to the leaky vasculature in the site. On page 2662 (DOI: 10.1002/pola.2776...

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Bibliographic Details
Published in:Journal of polymer science. Part A, Polymer chemistry Polymer chemistry, 2015-11, Vol.53 (22), p.iii-iv
Format: Article
Language:English
Online Access:Get full text
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Summary:Nano(hydro)gels were prepared as “smart” drug delivery systems to take advantage of the environmental conditions of tumor tissue. This image shows nanogels administered to circulate in the body and accumulate in the tumor due to the leaky vasculature in the site. On page 2662 (DOI: 10.1002/pola.27766), Mirian A. González‐Ayón, J. Adriana Sañudo‐Barajas, Lorenzo A. Picos‐Corrales, and Ángel Licea‐Claverie explain that the core of the nanogel is composed of temperature sensitive poly(N‐vinylcaprolactam) copolymerized with either vinylpyrrolidone or 2‐methacryloyloxybenzoic acid. The antineoplasic drug 5‐fluorouracil is delivered to the tumor when the conditions are met: pH 6 and T > 38 °C. The shell of the nanogels contains polyethyleneglycol to provide the nanogel with a biocompatible, immune system – “invisible” shell.
ISSN:0887-624X
1099-0518
DOI:10.1002/pola.27901