3D‐ΔΔG: A Dual‐Channel Prediction Model for Protein–Protein Binding Affinity Changes Following Mutation Based on Protein 3D Structures

Protein–protein interactions are crucial for cellular regulation, antigen–antibody interactions, and other vital processes within living organisms. However, mutations in amino acid residues have the potential to induce changes in protein–protein binding affinity (ΔΔG), which may contribute to the on...

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Bibliographic Details
Published in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2025-10, Vol.93 (10), p.1688-1700
Main Authors:	Wang, Yuxiang, Zhu, Yibo, Shi, Xiumin, Wang, Lu
Format:	Article
Language:	English
Subjects:	Affinity Amino Acid Sequence Amino acids Binding Binding Sites Cellular structure Computational Biology - methods Databases, Protein Datasets Deep Learning Graph representations Graphical representations Humans Models, Molecular Mutation Point mutation Prediction models pre‐trained protein language models Protein Binding Protein Conformation Protein engineering Protein interaction Proteins Proteins - chemistry Proteins - genetics Proteins - metabolism protein–protein binding affinity protein–protein interactions Thermodynamics ΔΔG
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