Microwave‐Assisted Suzuki‐Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3‐Arylazetidine

The efficient synthesis of 3‐arylazetidine derivatives is reported using a Nickel‐catalyzed Suzuki‐Miyaura coupling between arylboronic acids and a N‐BOC‐protected 3‐iodoazetidine under microwave irradiation. The reaction tolerates a great range of substituents such as electrodonating and electron w...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2017-09, Vol.2 (28), p.8841-8846
Main Authors: Dequirez, Geoffroy, Bourotte, Marilyne, Porras de Francisco, Esther, Remuiñan Blanco, Modesto J., Déprez, Benoit, Willand, Nicolas
Format: Article
Language:English
Subjects:
3-Arylazetidine
Heterocycles
Microwave irradiation
Nickel catalysis
Suzuki-Miyaura cross coupling
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Summary:The efficient synthesis of 3‐arylazetidine derivatives is reported using a Nickel‐catalyzed Suzuki‐Miyaura coupling between arylboronic acids and a N‐BOC‐protected 3‐iodoazetidine under microwave irradiation. The reaction tolerates a great range of substituents such as electrodonating and electron withdrawing groups opening the field of the diversity especially in the context of structure activity relationship studies. Suzuki‐Miyaura coupling between arylboronic acids and protected 3‐iodoazetidine under microwave irradiation provide the rapid access to a wide range of 3‐arylazetidine derivatives. This reaction is catalyzed with Nickel catalyst and under basic conditions.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201702101