NaN 3 /NH 4 Cl‐Promoted Aza‐Cyclization: A Convenient Route for Bio‐Active Diverse Isoindolinone Derivatives

An efficient substrate dependent NaN 3 /NH 4 Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthe...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2018-11, Vol.3 (42), p.11950-11956
Main Authors: Ali, Sk Asraf, Bhaumik, Sanjay, Jana, Akash, Manna, Susanta Kumar, Ikbal, Mohammed, Mandal, Arabinda, Bera, Anirban, Jana, Avijit, Samanta, Shubhankar
Format: Article
Language:English
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Summary:An efficient substrate dependent NaN 3 /NH 4 Cl promoted aza‐cyclization was developed via metal free cascade transformation. A wide variety of bicyclic/tricyclic isoindolinone derivative was achieved with excellent diastereoselectivity from achiral reagent system. This protocol also provided synthetic route of dopamine D 4 receptor in short way. The bio‐imaging study towards CHO cell line with our isoindolinone embedded new fluorophore was also demonstrated.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201802696