A Highly Efficient Synthesis of Pyrrolo[1,2‐a]pyrimidine Derivatives Containing 1,3‐Indandione Skeleton

The pyrimidines fused with pyrrole ring, pyrrolopyrimidines, showed broad applicability in medicinal chemistry. Herein, we synthesized the new derivatives (8 examples) of pyrrolo[1,2‐a]pyrimidine containing 1,3‐indandione skeleton by the use of triethylammonium thiolates, methyl iodide, and ketene a...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2019-07, Vol.4 (25), p.7446-7449
Main Authors: Alizadeh, Abdolali, Ghasemzadeh, Hossein, Xiao, Hong‐Ping
Format: Article
Language:English
Subjects:
cyclization
diamine
ketene aminals
nitro ketene dithioacetal
nitrogen heterocycles
pyrrolo[1,2-a]pyrimidines
ring contraction
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Summary:The pyrimidines fused with pyrrole ring, pyrrolopyrimidines, showed broad applicability in medicinal chemistry. Herein, we synthesized the new derivatives (8 examples) of pyrrolo[1,2‐a]pyrimidine containing 1,3‐indandione skeleton by the use of triethylammonium thiolates, methyl iodide, and ketene aminals via a one‐pot three‐component reaction. A series of pyrrolo[1,2‐a]pyrimidine containing 1,3‐indandione skeleton have been synthesized through the bicyclization strategy, from triethylammonium thiolates, methyl iodide and ketene aminals via a one‐pot three component reaction. The reactions were carried out at room temperature in DMF overnight.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201901263