Molecular Docking and Recent Advances in the Design and Development of Cholinesterase Inhibitor Scaffolds: Coumarin Hybrids

Alzheimer is a deadly neurodegenerative disease that commonly attacks elderly people around the world. Therefore, this disease has drawn attention among the researchers to find new potent drugs to treat Alzheimer disease (AD) more efficiently. Coumarin containing scaffold is a potential AD agent. Co...

Full description

Saved in:
Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2019-12, Vol.4 (48), p.14140-14156
Main Authors: Hasan, Aso Hameed, Amran, Syazwani Itri, Saeed Hussain, Faiq Hama, Jaff, Baram Ahmed, Jamalis, Joazaizulfazli
Format: Article
Language:English
Subjects:
Alzheimer disease
Cholinesterase inhibitors
Coumarin
Molecular docking
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alzheimer is a deadly neurodegenerative disease that commonly attacks elderly people around the world. Therefore, this disease has drawn attention among the researchers to find new potent drugs to treat Alzheimer disease (AD) more efficiently. Coumarin containing scaffold is a potential AD agent. Coumarin hybrids are frequently used as a template to design novel therapeutic agent for the treatment of AD, which are designed based on using molecular docking. As a result of docking studies shown that coumarin cores can occupy PAS by making extensive hydrophobic interactions with the residues in that region (mainly Trp279, Tyr70, Tyr121, Asp72, Phe290, Trp84, Phe330). The present review compiles research literature on the recent design strategies of coumarin hybrids with anti‐Alzheimer's activities and outlined docking studies. Coumarin compounds are well‐known as potent inhibitors against cholinesterase. In this review, a several synthetic approaches of coumarin hybrids have been reported and evaluated for their potential Alzheimer disease agent. The interaction modes of synthesized compounds with residues of enzymes have been investigated by molecular docking studies.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.201903607