Palladium‐Catalyzed One‐Pot Coupling / Cyclization through Mo(CO)6 as the Carbon Monoxide Donor: Synthesis of Quinazolinones

An efficient and rapid one‐pot synthesis of quinazolinone via a three‐component carbonylative coupling of 2‐aminobenzamide or 2‐aminobenzonitrile, Mo(CO)6 and aryl bromides has been developed recently. This method provide a new way to synthesize quinazolinone which has a wide substrate scope, good f...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2020-07, Vol.5 (25), p.7332-7337
Main Authors: Tao, Shou‐Wei, Liu, Rui‐Qing, Zhou, Jing‐Ya, Zhu, Yong‐Ming
Format: Article
Language:English
Subjects:
C1 building blocks
Carbonylation
Mo(CO)6
Quinazolinone
Transition metals
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Summary:An efficient and rapid one‐pot synthesis of quinazolinone via a three‐component carbonylative coupling of 2‐aminobenzamide or 2‐aminobenzonitrile, Mo(CO)6 and aryl bromides has been developed recently. This method provide a new way to synthesize quinazolinone which has a wide substrate scope, good functional group tolerance and mild reaction condition. A novel method for the synthesis of quinazolinone was realized by the catalysis of Pd(II), and this kind of compound is a class of important bioactive molecule The reaction was performed under a one‐pot mild condition, and the substrate has good applicability. And this achieved the transformation from both 2‐aminobenzamide and 2‐aminobenzonitrile to quinazolinone via the the construction of C−C bond and C−N bond.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202002111