Electrochemical Asymmetric Reduction of Ketoesters Induced by β‐Cyclodextrin Modified by (1S,2S)‐(+)‐1,2‐Diaminocyclohexane

• Published in: ChemistrySelect (Weinheim) 2021-01, Vol.6 (4), p.876-879
• Main Authors: Wang, Zhuo‐Lin, Zhao, Yi‐Jun, Xiong, Rui, Yang, Li‐Rong, Wang, Huan, Lu, Jia‐Xing
• Format: Article
• Language: English
• Subjects: (1S,2S)-(+)-1,2-diaminocyclohexane; Asymmetric catalysis; Electroreduction; Reduction; β-cyclodextrin
• ISSN: 2365-6549; 2365-6549
• DOI: 10.1002/slct.202004594

Chiral cyclohexanediamine was chemically bonded to β‐cyclodextrin as an inducer to induce the asymmetric reduction of ketoesters under electrochemical conditions. The reaction was carried out in an undivided glass cell to form the optically active products. The whole experiment was carried out under mild conditions without high temperature and high pressure. For the electrochemical asymmetric reduction reaction of ethyl benzoylacetate, 63 % yield and 50 % ee value can be obtained. Chiral cyclohexanediamine was chemically bonded to β‐cyclodextrin as an inducer to induce the asymmetric reduction of ketoesters under electrochemical conditions. The whole experiment was carried out under mild conditions without high temperature and high pressure. For the electrochemical asymmetric reduction reaction of ethyl benzoylacetate, 63 % yield and 50% ee value can be obtained.