Copper Catalyzed N‐Arylation of Amines in Ionic Liquid Using 1‐Aryltriazenes as Aryl Surrogates

Serving [TMG][CH3COO] ionic liquid as solvent and promoter, a competent access to unsymmetrically substituted secondary amine is accomplished through a copper catalyzed mono arylation of aromatic/aliphatic amines with diverse 1‐aryltriazenes. No base, ligand, co‐catalyst, additional promoter or addi...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2021-03, Vol.6 (11), p.2709-2715
Main Authors: Kim, Kang M., Kim, Kang Min
Format: Article
Language:English
Subjects:
1-Aryltriazenes
Aromatic Amine
C−C Coupling
Ionic Liquid
N-arylation
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Summary:Serving [TMG][CH3COO] ionic liquid as solvent and promoter, a competent access to unsymmetrically substituted secondary amine is accomplished through a copper catalyzed mono arylation of aromatic/aliphatic amines with diverse 1‐aryltriazenes. No base, ligand, co‐catalyst, additional promoter or additives are necessary to drive the reaction. Varied functional group tolerance, shorter reaction time, better product yield, recycle and re‐use of ionic liquid highlight this reaction as a better eco‐friendly alternative for the conventional synthesis. N‐arylation of aromatic/aliphatic amines was achieved using 1‐aryltriazenes as a coupling partner using copper catalyst in the presence of ionic liquid as solvent and acid promoter. A green approach is used over traditional method to synthesize these compounds in better yields without external base, ligand, co‐catalyst or additives. The eco‐friendly approach and re‐usability of ionic liquid are advantages in obtaining the better yields of products.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202100180