N‐Chlorosuccinimide Mediated Regioselective Sulfenylation and Halogenation of 4 H ‐Pyrido[1,2‐ a ]pyrimidin‐4‐ones at Room Temperature

A simple and efficient strategy for N‐chlorosuccinimide mediated regioselective C−H sulfenylation and halogenation of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones has been established at room temperature using aryl thiols and phenyliodine(III) diacetate (PIDA) respectively. This methodology tolerated a broa...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2022-12, Vol.7 (47)
Main Authors: Prajapati, Vaibhav D., Prajapati, Ronak V., Purohit, Vishal B., Avalani, Jemin R., Sapariya, Nirav H., Kamani, Ronak D., Karad, Sharad C., Raval, Dipak K.
Format: Article
Language:English
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Summary:A simple and efficient strategy for N‐chlorosuccinimide mediated regioselective C−H sulfenylation and halogenation of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones has been established at room temperature using aryl thiols and phenyliodine(III) diacetate (PIDA) respectively. This methodology tolerated a broad variety of functional groups to obtain structurally diverse sulfenyl and halogenated 4 H ‐pyrido[1,2‐a]pyrimidin‐4‐one derivatives under mild conditions. It delivered a range of products which can serve as the key precursors for the synthesis of complex products relevant to pharmaceutical applications.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202204126