DBU‐Promoted Solvent‐Free One‐Pot Multicomponent Synthesis of 2‐Amino‐1,4‐Dihydropyridines From β‐Enaminones, Aromatic Aldehydes and Malononitrile

The synthesis of 2‐amino‐1,4‐dihydropyridines was accomplished starting from β‐enaminones, aromatic aldehydes and malononitrile with DBU and without solvent. The reaction proceeds through a Knoevenegel condensation, which affords the benzylidine olefin intermediate. This can directly react with β‐en...

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Bibliographic Details
Published in:ChemistrySelect (Weinheim) 2024-07, Vol.9 (28), p.n/a
Main Authors: Chintha, Saikrishna, Medishetti, Nagaraju, Karangi, Maneesha, Atmakur, Krishnaiah
Format: Article
Language:English
Subjects:
1,4-Dihydropyridines
Benzylidine olefin
Multicomponent reactions (MCRs)
Solvent free
β-Enaminones
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Summary:The synthesis of 2‐amino‐1,4‐dihydropyridines was accomplished starting from β‐enaminones, aromatic aldehydes and malononitrile with DBU and without solvent. The reaction proceeds through a Knoevenegel condensation, which affords the benzylidine olefin intermediate. This can directly react with β‐enaminone, leading to the desired product. Simple reaction conditions with no solvent and good yields are the advantages of this protocol. The synthesis of 2‐amino‐1,4‐dihydropyridines was accomplished starting from β‐enaminones, aromatic aldehydes and malononitrile with DBU and without solvent. The reaction proceeds through a Knoevenegel condensation, which affords the benzylidine olefin intermediate. This can directly react with β‐enaminone, leading to the desired product. Simple reaction conditions with no solvent and good yields are the advantages of this protocol.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202401554