Hypotetraploidy in a Patient with Small Cell Carcinoma

• Published in: Experimental and molecular pathology 2000-02, Vol.68 (1), p.70-76
• Main Authors: Mark, Hon Fong L., Bai, Hongwei, Sotomayor, Edgar, Mark, Seamus, Rintels, Peter
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Bone Marrow Neoplasms - genetics; Bone Marrow Neoplasms - secondary; Carcinoma, Small Cell - genetics; Carcinoma, Small Cell - secondary; Fatal Outcome; Female; Hematologic and hematopoietic diseases; Humans; hypotetraploidy; Karyotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lung Neoplasms - genetics; Lung Neoplasms - pathology; Medical sciences; Middle Aged; near-tetraploidy; Neoplasms, Unknown Primary - genetics; Neoplasms, Unknown Primary - pathology; Polyploidy; small cell carcinoma; tetraploidy
• ISSN: 0014-4800; 1096-0945
• DOI: 10.1006/exmp.1999.2277

While numerical and structural chromosomal abnormalities characterize many hematopoietic and nonhematopoietic malignancies, the occurrence of polyploidy is by and large rare. We report here an interesting patient with small cell carcinoma (SCC) and hypotetraploidy initially referred to us because of a question of acute nonlymphocytic leukemia, M3 subtype, with a question of a 15;17 translocation characteristic of acute promyelocytic leukemia. However, the patient did not have a 15;17 translocation and the final hematopathologic analysis of the bone marrow aspirates and immunohistochemistry studies subsequently revealed the patient to have SCC. Small cell carcinoma is a highly malignant and a very aggressive neoplasm. A review of the literature, using Medline, Cancerlit, and the Science Citation Index, revealed that in most, if not all, reports, the presence of polyploidy is noted as a rare entity. In leukemia, reports of polyploidy point to a distinct category of patients with a poor risk for which more intensive treatment is needed. Limited information is currently available to assess the risk of polyploidy in small cell carcinoma. Our case is important not only because of the relative rarity of polyploidy, but also because insights gained from the study of this and other similar patients may help shed additional light on the mechanism of carcinogenesis, which is not fully known to date. As polyploidization is a manifestation of genetic instability and as genetic instability has been implicated in the genesis and progression of many cancers, it is perhaps not too surprising that polyploidy in our case was associated with a poor disease outcome. The patient has since expired.