A phase II study of m-AMSA in patients with primary liver cancer

Thirty-five evaluable patients with histologically confirmed primary liver cancer (PLC) were treated with m-AMSA. All patients had measurable disease and an Eastern Cooperative Oncology Group (ECOG) performance status of 1, 2, or 3. m-AMSA 120 mg/M2 IV was given every 21 days. Hemopoietic suppressio...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1981, Vol.6 (2), p.127
Main Authors: Falkson, G, Coetzer, B, Klaassen, D J
Format: Article
Language:English
Subjects:
Adult
Aged
Aminoacridines - adverse effects
Aminoacridines - therapeutic use
Amsacrine
Antineoplastic Agents - therapeutic use
Drug Evaluation
Female
Humans
Liver Neoplasms - drug therapy
Male
Middle Aged
Time Factors
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Summary:Thirty-five evaluable patients with histologically confirmed primary liver cancer (PLC) were treated with m-AMSA. All patients had measurable disease and an Eastern Cooperative Oncology Group (ECOG) performance status of 1, 2, or 3. m-AMSA 120 mg/M2 IV was given every 21 days. Hemopoietic suppression was the major side-effect. In 26 of 35 patients (25 with leukopenia and five with thrombocytopenia), this toxic effect was documented. There was only one patient who had a partial remission (PR) of 51 weeks' duration, but a no change (NC) status was maintained in 28 patients for at least 6 weeks. The median survival time of all patients on this study was 13 weeks, which compares favorably with most previous studies.
ISSN:0344-5704
1432-0843
DOI:10.1007/BF00262329