The effect of timing of a single injection on the toxicity of methotrexate in the rat

The possibility of a circadian rhythm in the toxicity of methotrexate was investigated in rats after a single intravenous bolus. Indices of haematological, renal and hepatic toxicity were studied, as were the pharmacokinetics of the drug. All the parameters showed a circadian variation, with maximum...

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Bibliographic Details
Published in:Cancer chemotherapy and pharmacology 1982, Vol.9 (2), p.114-117
Main Authors: English, J, Aherne, G W, Marks, V
Format: Article
Language:English
Subjects:
Animals
Aspartate Aminotransferases - blood
Blood Cell Count
Circadian Rhythm
Half-Life
Kinetics
Male
Methotrexate - administration & dosage
Methotrexate - toxicity
Rats
Time Factors
Urea - blood
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Summary:The possibility of a circadian rhythm in the toxicity of methotrexate was investigated in rats after a single intravenous bolus. Indices of haematological, renal and hepatic toxicity were studied, as were the pharmacokinetics of the drug. All the parameters showed a circadian variation, with maximum toxicity occurring after dosage of 06.00 h and minimum toxicity after dosage at midnight. Administration at the other two time points, 12.00 h and 18.00 h, gave intermediate results.
ISSN:0344-5704
1432-0843
DOI:10.1007/bf00265390