Comparison of the cardiostimulatory effects of acetylcholine and nicotine on the working Guinea-pig heart

The isolated working guinea-pig heart was used to compare the cardiostimulatory effects of acetylcholine and nicotine observed in the presence of atropine. Both agonists increased aortic pressure, left ventricular pressure, left ventricular dP/dt, cardiac output, and ventricular cyclic AMP levels. T...

Full description

Saved in:
Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1979-12, Vol.310 (2), p.97-101
Main Authors: Rodgers, R L, Moore, J I, Hornbrook, K R
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Animals
Cardiac Output - drug effects
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Drug Interactions
Guinea Pigs
Heart - drug effects
Hexamethonium Compounds - pharmacology
In Vitro Techniques
Male
Myocardial Contraction - drug effects
Nicotine - pharmacology
Propranolol - pharmacology
Stimulation, Chemical
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The isolated working guinea-pig heart was used to compare the cardiostimulatory effects of acetylcholine and nicotine observed in the presence of atropine. Both agonists increased aortic pressure, left ventricular pressure, left ventricular dP/dt, cardiac output, and ventricular cyclic AMP levels. These responses were qualitatively and quantitatively similar to the effects of exogenous norepinephrine. Hexamethonium treatment abolished the responses to acetylcholine and to nicotine. However, several differences in the responses of the two agonists were also observed with respect to: 1) the effect of propranolol pretreatment, 2) selective effects on coronary and aortic flow rates, 3) coefficients of correlation between ventricular cyclic AMP and changes in dP/dt, and 4) the "autoinhibition" effect. The results support the view that the cardiostimulatory effects of acetylcholine are due entirely to endogenous catecholamine release, but that the effects of nicotine may involve an additional action.
ISSN:0028-1298
1432-1912
DOI:10.1007/BF00500273