Effect of nicotine on serum secretin and exocrine pancreatic secretion

The effect of nicotine (100 mug/kg hr-1) on serum secretin and pancreatic secretions was studied in dogs with chronic pancreatic fistulas. Release of immunoreactive secretin (IRS) was stimulated by intraduodenal infusion of HCl (9.6 mEq/30 min). Pancreatic flow rate and bicarbonate and protein secre...

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Bibliographic Details
Published in:American journal of digestive diseases 1976-11, Vol.21 (11), p.974-977
Main Authors: Boden, G, Shore, L S, Essa-Koumar, N, Landor, J H
Format: Article
Language:English
Subjects:
Animals
Dogs
Duodenum - drug effects
Hydrochloric Acid - administration & dosage
Metabolic Clearance Rate - drug effects
Nicotine - pharmacology
Pancreatic Juice - drug effects
Pancreatic Juice - metabolism
Secretin - administration & dosage
Secretin - blood
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Summary:The effect of nicotine (100 mug/kg hr-1) on serum secretin and pancreatic secretions was studied in dogs with chronic pancreatic fistulas. Release of immunoreactive secretin (IRS) was stimulated by intraduodenal infusion of HCl (9.6 mEq/30 min). Pancreatic flow rate and bicarbonate and protein secretions were stimulated either by intestinal acidification or infusion of exogenous secretin (1.0 IU/kg hr-1). It was found that nicotine delayed the appearance of peak IRS concentrations in response to intraduodenal HCl by about 20 min. However, nicotine had no effect on the total amount of IRS released nor was this delay accompanied by a similar delay in the appearance of peak bicarbonate output. Furthermore, nicotine did not affect pancreatic secretory function stimulated by either HCl or exogenous secretin. These data do not support the thesis that nicotine plays an important role in the pathogenesis of duodenal ulcers in smokers by inhibiting the pancreatic secretion of bicarbonate.
ISSN:0002-9211
1573-2568
DOI:10.1007/BF01071910