Insulin therapy prevents spontaneous recovery from streptozotocin-induced diabetes in Syrian hamsters : an autoradiographic and immunohistochemical study

Streptozotocin (Sz) given as a single dose of 50 mg/kg body wt. caused severe diabetes in Syrian hamsters. However, the level of blood glucose decreased gradually after 21 days post-Sz and reached the near normal level at 70 days in 90% of hamsters. The recovery from diabetes was associated with the...

Full description

Saved in:
Bibliographic Details
Published in:Virchows Archiv A Pathological Anatomy and Histopathology 1990-07, Vol.417 (4), p.333-341
Main Authors: POUR, P. M, DUCKWORTH, W, CARLSON, K, KAZAKOFF, K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Glucose - analysis
Cell Division - drug effects
Cricetinae
Diabetes Mellitus, Experimental - pathology
Diabetes Mellitus, Experimental - physiopathology
Fundamental and applied biological sciences. Psychology
Insulin - pharmacology
Islets of Langerhans - drug effects
Islets of Langerhans - pathology
Islets of Langerhans - physiopathology
Male
Pancreas - cytology
Pancreas - drug effects
Pancreas - pathology
Streptozocin
Vertebrates: endocrinology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Streptozotocin (Sz) given as a single dose of 50 mg/kg body wt. caused severe diabetes in Syrian hamsters. However, the level of blood glucose decreased gradually after 21 days post-Sz and reached the near normal level at 70 days in 90% of hamsters. The recovery from diabetes was associated with the regeneration of the beta-cells of islets and a reduction in the initially increased number of alpha- and delta-cells. Daily treatment of diabetic hamsters with insulin was associated with the persistence of severe diabetes, lack of or minimal tendency for beta-cell regeneration and sustained hyperplasia of alpha- and delta-cells in 90% of hamsters. Insulin also inhibited DNA synthesis (as measured by incorporation of tritiated thymidine), in ductal, ductular and acinar cells in Sz-pretreated hamsters but not in normoglycemic control hamsters treated with insulin alone. The results demonstrate a deleterious effect of exogenous insulin in the course of Sz-induced diabetes in hamsters.
ISSN:0174-7398
1432-2307
DOI:10.1007/BF01605785