Assessment of myocardial area at risk by technetium-99m sestamibi during coronary artery occlusion : comparison between three tomographic methods of quantification

The aim of this study was to directly compare three currently used quantitative methods of analysis of technetium-99m sestamibi images in patients with selective balloon-induced transmural ischaemia. The area at risk (AR) was assessed in 19 patients undergoing single-vessel percutaneous transluminal...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1996, Vol.23 (1), p.31-39
Main Authors: CERIANI, L, VERNA, E, GIOVANELLA, L, BIANCHI, L, RONCARI, G, TAROLO, G. L
Format: Article
Language:English
Subjects:
Angioplasty, Balloon, Coronary
Biological and medical sciences
Cardiovascular system
Coronary Disease - diagnostic imaging
Coronary Disease - therapy
Female
Heart - diagnostic imaging
Humans
Image Processing, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Myocardial Ischemia - diagnostic imaging
Prognosis
Radionuclide investigations
Reproducibility of Results
Risk Factors
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon - methods
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Summary:The aim of this study was to directly compare three currently used quantitative methods of analysis of technetium-99m sestamibi images in patients with selective balloon-induced transmural ischaemia. The area at risk (AR) was assessed in 19 patients undergoing single-vessel percutaneous transluminal coronary angioplasty by injecting the 99mTc-sestamibi at the time of coronary artery occlusion during balloon inflation. After imaging, the patients were classified according to localization of the perfusion defect as having anteroseptal (group I, 11 patients) or posterolateral defects (group II, eight patients). The planimetric technique based on polar maps, proposed by Verani et al. (J Am Coll Cardiol, 1988) (method A), the method described by Tamaki et al. (Circulation, 1982) (method B) and the technique validated by O Connor et al. (Eur J Nucl Med, 1990) (method C) were tested. Three threshold values of 45%, 50% and 60% of the maximum left ventricular count were used to define the limits of the perfusion defect. The mean values of the AR calculated by the three techniques with the original cut-off level (method A=16.5%+/-12.9; method B=10.4%+/-7.6%; method C=29.6%+/-15.7%) were statistically different (one-way analysis of variance: P
ISSN:0340-6997
1619-7089
DOI:10.1007/BF01736987