The contribution of calcitonin gene-related peptide (CGRP) to neurogenic vasodilator responses

The neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator in the microcirculation of many tissues including the skin and joint. In order to elucidate the mechanism of endogenous CGRP release, we have used a multiple site 133Xe clearance technique to measure local blood flow cha...

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Bibliographic Details
Published in:Agents and Actions 1993-06, Vol.38 Spec No (S2), p.C19-C21
Main Authors: Brain, S D, Hughes, S R, Cambridge, H, O'Driscoll, G
Format: Article
Language:English
Subjects:
Animals
Blood Flow Velocity - drug effects
Calcitonin Gene-Related Peptide - physiology
Capsaicin - pharmacology
Dose-Response Relationship, Drug
Humans
Microcirculation - drug effects
Rabbits
Skin - blood supply
Skin - innervation
Vasodilator Agents - pharmacology
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Summary:The neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator in the microcirculation of many tissues including the skin and joint. In order to elucidate the mechanism of endogenous CGRP release, we have used a multiple site 133Xe clearance technique to measure local blood flow changes in response to agents injected intradermally in the rabbit. Capsaicin (100 nmol/site) and human alpha CGRP (3 pmol/site) stimulated similar increases in blood flow and, in both cases, the effect was totally abolished by the CGRP antagonist, CGRP8-37 (1 nmol/site). By contrast, the nitric oxide synthase inhibitor L-nitro arginine methyl ester (L-NAME, 30 nmol/site) had little effect on human alpha CGRP-induced vasodilation, but caused significant inhibition of the response to capsaicin (p < 0.05). These results show that increased blood flow in rabbit skin caused by exogenous CGRP is independent of nitric oxide. In addition, however, they suggest that nitric oxide is required for either the release of endogenous CGRP from capsaicin-sensitive nerves or its subsequent activity.
ISSN:0065-4299
1420-908X
DOI:10.1007/bf01991124