Blood flow and mucoid cap protect against penetration of carcinogens into superficially injured gastric mucosa of rats

In this study we tested the influence of blood flow and the mucoid cap on the penetration of carcinogens to the proliferative cells in the injures rat gastric mucosa. Ten minutes after mucosal exposure to 4.5 mol/liter NaCl, N-[3H]methyl-N'-nitro-N-nitrosoguanidine was instilled intragastricall...

Full description

Saved in:
Bibliographic Details
Published in:Digestive diseases and sciences 1995-08, Vol.40 (8), p.1720-1728
Main Authors: SØRBYE, H, ØVREBØ, K, GISLASON, H, KVINNSLAND, S, SVANES, K
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Celiac Artery
Chemical agents
Gastric Mucosa - blood supply
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Ligation
Male
Medical sciences
Methylnitronitrosoguanidine - pharmacokinetics
Mucus - physiology
Rats
Rats, Wistar
Regional Blood Flow
Stomach Neoplasms - chemically induced
Stomach Neoplasms - physiopathology
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study we tested the influence of blood flow and the mucoid cap on the penetration of carcinogens to the proliferative cells in the injures rat gastric mucosa. Ten minutes after mucosal exposure to 4.5 mol/liter NaCl, N-[3H]methyl-N'-nitro-N-nitrosoguanidine was instilled intragastrically. Hypertonic saline caused superficial mucosal damage, formation of a mucoid cap, high gastric mucosal blood flow, and a large flux of fluid into the gastric lumen. The mean percentage of S-phase cells labeled with carcinogen (the cell population at risk for N-methyl-N'nitro-N-nitrosoguanidine-induced carcinogenesis) in the antrum and corpus was 0.2 and 0.2, respectively, in the injury control group, 10.1 and 2.0 after removal of the mucoid cap, 1.5 and 9.8 after celiac artery ligation, and 28.2 and 21.9 after removal of the mucoid cap and celiac artery ligation. These results show that both the mucoid cap and gastric mucosal blood flow protect against penetration of carcinogens into the superficially injured gastric mucosa.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf02212693