Time-dependent exacerbation of amphetamine-induced taste aversions following exposure to footshock

Previous studies have shown that stressors attenuate LiCI-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies examined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshoc...

Full description

Saved in:
Bibliographic Details
Published in:Psychopharmacologia 1996-05, Vol.125 (1), p.43-49
Main Authors: BOWERS, W. J, GINGRAS, M. A, AMIT, Z
Format: Article
Language:English
Subjects:
Amphetamine - pharmacology
Analysis of Variance
Animal
Animals
Biological and medical sciences
Conditioning
Drinking - drug effects
Electroshock
Fundamental and applied biological sciences. Psychology
Learning. Memory
Male
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Saccharin - metabolism
Taste - drug effects
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have shown that stressors attenuate LiCI-induced conditioned taste aversions (CTA) but not morphine-induced CTA. The current studies examined the effects of footshock on the acquisition and extinction of amphetamine-induced CTA. Experiment 1 demonstrated that exposure to 30 footshocks between saccharin consumption and amphetamine injections did not alter either the acquisition or the extinction of amphetamine-CTA. Experiment 2 demonstrated that exposure to the same shock parameters 2 and 4 days before saccharin-amphetamine pairing increased the magnitude of amphetamine-CTA after one saccharin-amphetamine pairing and delayed the recovery from the CTA. Experiment 2 also demonstrated that footshock increased the initial neophobic response to novel saccharin but did not alter subsequent saccharin consumption among saline-injected animals. These results indicate that stress-induced facilitation of amphetamine CTA are time-dependent and contrast with reports that stressors attenuate LiCI CTA. They also add support to the contention that CTAs induced by self-administered drugs like amphetamine are qualitatively different from CTAs induced by toxic substances like LiCL.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF02247391