Enhanced sensitivity to salt-induced high blood pressure in diabetes mellitus

Salt-induced high blood pressure in diabetic rats was compared with that in non-diabetic (control) rats. Before the rats had eaten the high-salt diet, the diabetic group exhibited significantly greater pressor response to noradrenaline (100 ng/100 g body weight) than the controls (P < 0.05). When...

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Bibliographic Details
Published in:Research in experimental medicine 1994-12, Vol.194 (3), p.197-202
Main Authors: ORIE, N. N, ALOAMAKA, C. P, IYAWE, V. I
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure
Diabetes Mellitus, Experimental - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Hypertension - etiology
Hypertension - physiopathology
Male
Medical sciences
Norepinephrine - administration & dosage
Rats
Rats, Wistar
Sodium, Dietary - administration & dosage
Sodium, Dietary - adverse effects
Vascular Resistance - drug effects
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Summary:Salt-induced high blood pressure in diabetic rats was compared with that in non-diabetic (control) rats. Before the rats had eaten the high-salt diet, the diabetic group exhibited significantly greater pressor response to noradrenaline (100 ng/100 g body weight) than the controls (P < 0.05). When the rats were given a high-salt diet, a significant increase in blood pressure was recorded 4 weeks earlier in the diabetic than in the control group (P < 0.05); this increase occurred after 2 weeks in the diabetic group, but after 6 weeks of high-salt diet in the controls. The enhanced state of vascular reactivity in the diabetic rats was probably responsible for their enhanced sensitivity to salt-induced high blood pressure.
ISSN:0300-9130
1433-8580
DOI:10.1007/BF02576380