New cytotoxic benzopyrans from the leaves ofMallotus apelta

Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5, 7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves ofMallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated...

Full description

Saved in:
Bibliographic Details
Published in:Archives of pharmacal research 2005-10, Vol.28 (10), p.1131-1134
Main Authors: Kiem, Phan Van, Dang, Nguyen Hai, Bao, Ha Viet, Huong, Hoang Thanh, Minh, Chau Van, Huong, Le Mai, Lee, Jung Joon, Kim, Young Ho
Format: Article
Language:English
Subjects:
benzopyrans
carcinoma
cells
chemical structure
cytotoxicity
Euphorbiaceae
hepatoma
human cell lines
humans
inhibitory concentration 50
leaves
nuclear magnetic resonance spectroscopy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c1001-5e8c7267cae55b5c63d7c567dcef28ec3cf2355c8245bb61324f9c5efcdbe3c73
cites cdi_FETCH-LOGICAL-c1001-5e8c7267cae55b5c63d7c567dcef28ec3cf2355c8245bb61324f9c5efcdbe3c73
container_end_page 1134
container_issue 10
container_start_page 1131
container_title Archives of pharmacal research
container_volume 28
creator Kiem, Phan Van
Dang, Nguyen Hai
Bao, Ha Viet
Huong, Hoang Thanh
Minh, Chau Van
Huong, Le Mai
Lee, Jung Joon
Kim, Young Ho
description Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5, 7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves ofMallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D- 2D-NMR and MS spectra. Compound1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC₅₀: 0.49 μg/mL) and rhabdosarcoma (RD, IC₅₀: 0.54 μg/mL), while compound2 showed moderate activity against Hep-2 cell line (IC₅₀, 4.22μg/mL), byin vitro assay.
doi_str_mv 10.1007/BF02972974
format article
fullrecord <record><control><sourceid>fao_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_BF02972974</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US201600020891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1001-5e8c7267cae55b5c63d7c567dcef28ec3cf2355c8245bb61324f9c5efcdbe3c73</originalsourceid><addsrcrecordid>eNpFj01LAzEURYMoWKsb_4BZC6MvSV8ygystVoWqC-16yLy-aGXaDMn4UX-9lQrChbs5XO4R4ljBmQJw51cT0JXbZLQjBqpytjCutLtiABpNYbWt9sVBzm8AxiLiQFw88KekdR_7-LUg2fDqO3br5FdZhhSXsn9l2bL_4CxjuPdtG_v3LH3Hbe8PxV7wbeajvx6K2eT6eXxbTB9v7saX04I2n1SBXJLT1pFnxAbJmrkjtG5OHHTJZChog0ilHmHTWGX0KFSEHGjesCFnhuJ0u0sp5pw41F1aLH1a1wrqX-36X3sDn2zh4GPtX9Ii17MnDcoCgIayUuYHKg1T_A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>New cytotoxic benzopyrans from the leaves ofMallotus apelta</title><source>Springer Nature</source><creator>Kiem, Phan Van ; Dang, Nguyen Hai ; Bao, Ha Viet ; Huong, Hoang Thanh ; Minh, Chau Van ; Huong, Le Mai ; Lee, Jung Joon ; Kim, Young Ho</creator><creatorcontrib>Kiem, Phan Van ; Dang, Nguyen Hai ; Bao, Ha Viet ; Huong, Hoang Thanh ; Minh, Chau Van ; Huong, Le Mai ; Lee, Jung Joon ; Kim, Young Ho</creatorcontrib><description>Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5, 7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves ofMallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D- 2D-NMR and MS spectra. Compound1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC₅₀: 0.49 μg/mL) and rhabdosarcoma (RD, IC₅₀: 0.54 μg/mL), while compound2 showed moderate activity against Hep-2 cell line (IC₅₀, 4.22μg/mL), byin vitro assay.</description><identifier>ISSN: 0253-6269</identifier><identifier>EISSN: 1976-3786</identifier><identifier>DOI: 10.1007/BF02972974</identifier><language>eng</language><publisher>Pharmaceutical Society of Korea</publisher><subject>benzopyrans ; carcinoma ; cells ; chemical structure ; cytotoxicity ; Euphorbiaceae ; hepatoma ; human cell lines ; humans ; inhibitory concentration 50 ; leaves ; nuclear magnetic resonance spectroscopy</subject><ispartof>Archives of pharmacal research, 2005-10, Vol.28 (10), p.1131-1134</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1001-5e8c7267cae55b5c63d7c567dcef28ec3cf2355c8245bb61324f9c5efcdbe3c73</citedby><cites>FETCH-LOGICAL-c1001-5e8c7267cae55b5c63d7c567dcef28ec3cf2355c8245bb61324f9c5efcdbe3c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Kiem, Phan Van</creatorcontrib><creatorcontrib>Dang, Nguyen Hai</creatorcontrib><creatorcontrib>Bao, Ha Viet</creatorcontrib><creatorcontrib>Huong, Hoang Thanh</creatorcontrib><creatorcontrib>Minh, Chau Van</creatorcontrib><creatorcontrib>Huong, Le Mai</creatorcontrib><creatorcontrib>Lee, Jung Joon</creatorcontrib><creatorcontrib>Kim, Young Ho</creatorcontrib><title>New cytotoxic benzopyrans from the leaves ofMallotus apelta</title><title>Archives of pharmacal research</title><description>Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5, 7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves ofMallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D- 2D-NMR and MS spectra. Compound1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC₅₀: 0.49 μg/mL) and rhabdosarcoma (RD, IC₅₀: 0.54 μg/mL), while compound2 showed moderate activity against Hep-2 cell line (IC₅₀, 4.22μg/mL), byin vitro assay.</description><subject>benzopyrans</subject><subject>carcinoma</subject><subject>cells</subject><subject>chemical structure</subject><subject>cytotoxicity</subject><subject>Euphorbiaceae</subject><subject>hepatoma</subject><subject>human cell lines</subject><subject>humans</subject><subject>inhibitory concentration 50</subject><subject>leaves</subject><subject>nuclear magnetic resonance spectroscopy</subject><issn>0253-6269</issn><issn>1976-3786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpFj01LAzEURYMoWKsb_4BZC6MvSV8ygystVoWqC-16yLy-aGXaDMn4UX-9lQrChbs5XO4R4ljBmQJw51cT0JXbZLQjBqpytjCutLtiABpNYbWt9sVBzm8AxiLiQFw88KekdR_7-LUg2fDqO3br5FdZhhSXsn9l2bL_4CxjuPdtG_v3LH3Hbe8PxV7wbeajvx6K2eT6eXxbTB9v7saX04I2n1SBXJLT1pFnxAbJmrkjtG5OHHTJZChog0ilHmHTWGX0KFSEHGjesCFnhuJ0u0sp5pw41F1aLH1a1wrqX-36X3sDn2zh4GPtX9Ii17MnDcoCgIayUuYHKg1T_A</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Kiem, Phan Van</creator><creator>Dang, Nguyen Hai</creator><creator>Bao, Ha Viet</creator><creator>Huong, Hoang Thanh</creator><creator>Minh, Chau Van</creator><creator>Huong, Le Mai</creator><creator>Lee, Jung Joon</creator><creator>Kim, Young Ho</creator><general>Pharmaceutical Society of Korea</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200510</creationdate><title>New cytotoxic benzopyrans from the leaves ofMallotus apelta</title><author>Kiem, Phan Van ; Dang, Nguyen Hai ; Bao, Ha Viet ; Huong, Hoang Thanh ; Minh, Chau Van ; Huong, Le Mai ; Lee, Jung Joon ; Kim, Young Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1001-5e8c7267cae55b5c63d7c567dcef28ec3cf2355c8245bb61324f9c5efcdbe3c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>benzopyrans</topic><topic>carcinoma</topic><topic>cells</topic><topic>chemical structure</topic><topic>cytotoxicity</topic><topic>Euphorbiaceae</topic><topic>hepatoma</topic><topic>human cell lines</topic><topic>humans</topic><topic>inhibitory concentration 50</topic><topic>leaves</topic><topic>nuclear magnetic resonance spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kiem, Phan Van</creatorcontrib><creatorcontrib>Dang, Nguyen Hai</creatorcontrib><creatorcontrib>Bao, Ha Viet</creatorcontrib><creatorcontrib>Huong, Hoang Thanh</creatorcontrib><creatorcontrib>Minh, Chau Van</creatorcontrib><creatorcontrib>Huong, Le Mai</creatorcontrib><creatorcontrib>Lee, Jung Joon</creatorcontrib><creatorcontrib>Kim, Young Ho</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><jtitle>Archives of pharmacal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kiem, Phan Van</au><au>Dang, Nguyen Hai</au><au>Bao, Ha Viet</au><au>Huong, Hoang Thanh</au><au>Minh, Chau Van</au><au>Huong, Le Mai</au><au>Lee, Jung Joon</au><au>Kim, Young Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New cytotoxic benzopyrans from the leaves ofMallotus apelta</atitle><jtitle>Archives of pharmacal research</jtitle><date>2005-10</date><risdate>2005</risdate><volume>28</volume><issue>10</issue><spage>1131</spage><epage>1134</epage><pages>1131-1134</pages><issn>0253-6269</issn><eissn>1976-3786</eissn><abstract>Two new benzopyrans 6-[1′-oxo-3′(R)-hydroxy-butyl]-5, 7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1′-oxo-3′(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves ofMallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D- 2D-NMR and MS spectra. Compound1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC₅₀: 0.49 μg/mL) and rhabdosarcoma (RD, IC₅₀: 0.54 μg/mL), while compound2 showed moderate activity against Hep-2 cell line (IC₅₀, 4.22μg/mL), byin vitro assay.</abstract><pub>Pharmaceutical Society of Korea</pub><doi>10.1007/BF02972974</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0253-6269
ispartof Archives of pharmacal research, 2005-10, Vol.28 (10), p.1131-1134
issn 0253-6269
1976-3786
language eng
recordid cdi_crossref_primary_10_1007_BF02972974
source Springer Nature
subjects benzopyrans
carcinoma
cells
chemical structure
cytotoxicity
Euphorbiaceae
hepatoma
human cell lines
humans
inhibitory concentration 50
leaves
nuclear magnetic resonance spectroscopy
title New cytotoxic benzopyrans from the leaves ofMallotus apelta
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T12%3A10%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-fao_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20cytotoxic%20benzopyrans%20from%20the%20leaves%20ofMallotus%20apelta&rft.jtitle=Archives%20of%20pharmacal%20research&rft.au=Kiem,%20Phan%20Van&rft.date=2005-10&rft.volume=28&rft.issue=10&rft.spage=1131&rft.epage=1134&rft.pages=1131-1134&rft.issn=0253-6269&rft.eissn=1976-3786&rft_id=info:doi/10.1007/BF02972974&rft_dat=%3Cfao_cross%3EUS201600020891%3C/fao_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1001-5e8c7267cae55b5c63d7c567dcef28ec3cf2355c8245bb61324f9c5efcdbe3c73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true