A comparison between metabolic syndrome post-hematopoietic stem cell transplantation and spontaneously occurring metabolic syndrome

Background : Hematopoietic stem cell transplantation (HSCT) is used in the treatment of several hematological and non-hematological disorders. An increasing number of long-term survivors recover from their primary disease, but they are at risk of adverse late effects, including metabolic syndrome (M...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2011, Vol.34 (1), p.e6-e11
Main Authors: Airaghi, L., Usardi, P., Forti, S., Orsatti, A., Baldini, M., Annaloro, C., Lambertenghi Deliliers, G.
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adult
Body Mass Index
C-Reactive Protein - analysis
Case-Control Studies
Endocrinology
Female
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic Stem Cell Transplantation - statistics & numerical data
Humans
Insulin - blood
Insulin Resistance - physiology
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Metabolic Syndrome - etiology
Metabolic Syndrome - metabolism
Middle Aged
Original Articles
Tumor Necrosis Factor-alpha - blood
Young Adult
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Summary:Background : Hematopoietic stem cell transplantation (HSCT) is used in the treatment of several hematological and non-hematological disorders. An increasing number of long-term survivors recover from their primary disease, but they are at risk of adverse late effects, including metabolic syndrome (MS), which seems to be common in long-term survivors of HSCT. Aim : To compare common metabolic parameters and adipohormone profiles in post-transplant and spontaneously occurring or “classic” MS patients. Subjects and methods : Post-transplant MS patients (15 women and 14 men; 49.8±9.3 yr) were compared to “classic” MS patients (15 women and 14 men; 52.9±8.0 yr). For each subject a record of conventional clinical parameters was made; moreover, serum leptin, insulin, quantitative C-reactive protein (CRP), tumor necrosis factor-α [TNF-α], and adiponectin concentrations were measured. Results : The patients with post-HSCT MS had significantly higher levels of leptin, CRP, and TNF-α than the patients with “classic” MS. A generalized linear model comprising serum insulin ( p =0.022), body mass index ( p
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03346702