Synthesis and antimicrobial activity of some bisoctahydroxanthene-1,8-dione derivatives

The bisoctahydroxanthen-1,8-dione derivatives were synthesized effectively via p - dodecylbenzene sulfonic acid the catalysed cyclocondensation of cyclic 1,3-dicarbonyl compounds with 1,3- or 1,4-benzene dicarboxaldehydes in water. The products were obtained with yield ranged from 75 to 95%. The str...

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Bibliographic Details
Published in:Medicinal chemistry research 2011-11, Vol.20 (8), p.1214-1219
Main Authors: Kaya, Muharrem, Basar, Erhan, Colak, Ferdağ
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:The bisoctahydroxanthen-1,8-dione derivatives were synthesized effectively via p - dodecylbenzene sulfonic acid the catalysed cyclocondensation of cyclic 1,3-dicarbonyl compounds with 1,3- or 1,4-benzene dicarboxaldehydes in water. The products were obtained with yield ranged from 75 to 95%. The structures of compounds were characterized by FT-IR, 1 H-NMR and elemental analysis. The antimicrobial properties of compounds against pathogens were investigated by the disc-diffusion method. These compounds were evaluated for potential antimicrobial activity against Gram-positive ( Staphylococcus aureus , Bacillus cereus , S. epidermidis and Nocardia canis ), Gram-negative bacteria ( Escherichia coli, Proteus vulgaris and Pseudomonas aeroginosa) , yeasts ( Candida albicans and Rhodotorula rubra ) and mold ( Aspergillus niger ). The growth of S. aureus , B. cereus , S. epidermidis , E. coli , C. albicans , R. rubra and A. niger were inhibited by 3f and 3g compounds. All compounds were resistant against Gram-negative bacteria ( Proteus vulgaris and Pseudomonas aerginosa ) and results were upon comparison with reference discs.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-010-9459-2