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5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents
In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated...
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| Published in: | Medicinal chemistry research 2013-05, Vol.22 (5), p.2293-2302 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c288t-89381e78f08f59eb131d65cf8a7518fb612c4522fc8ea7eca77bf03e255d20ac3 |
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| cites | cdi_FETCH-LOGICAL-c288t-89381e78f08f59eb131d65cf8a7518fb612c4522fc8ea7eca77bf03e255d20ac3 |
| container_end_page | 2302 |
| container_issue | 5 |
| container_start_page | 2293 |
| container_title | Medicinal chemistry research |
| container_volume | 22 |
| creator | Hosseinzadeh, Nouraddin Hasani, Mohammad Foroumadi, Alireza Nadri, Hamid Emami, Saeed Samadi, Nasrin Faramarzi, Mohammad Ali Saniee, Parastoo Siavoshi, Farideh Abadian, Neda Mahmoudjanlou, Yasaman Sakhteman, Amirhossein Moradi, Alireza Shafiee, Abbas |
| description | In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as
Helicobacter pylori
strains. Biological data indicated that 5-nitrofuran analog
5a
and 5-nitroimidazole analog
7a
containing no substitutions on the thiazole ring were the most potent compounds. |
| doi_str_mv | 10.1007/s00044-012-0224-6 |
| format | article |
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Helicobacter pylori
strains. Biological data indicated that 5-nitrofuran analog
5a
and 5-nitroimidazole analog
7a
containing no substitutions on the thiazole ring were the most potent compounds.</description><identifier>ISSN: 1054-2523</identifier><identifier>EISSN: 1554-8120</identifier><identifier>DOI: 10.1007/s00044-012-0224-6</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Original Research ; Pharmacology/Toxicology</subject><ispartof>Medicinal chemistry research, 2013-05, Vol.22 (5), p.2293-2302</ispartof><rights>Springer Science+Business Media, LLC 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c288t-89381e78f08f59eb131d65cf8a7518fb612c4522fc8ea7eca77bf03e255d20ac3</citedby><cites>FETCH-LOGICAL-c288t-89381e78f08f59eb131d65cf8a7518fb612c4522fc8ea7eca77bf03e255d20ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Hosseinzadeh, Nouraddin</creatorcontrib><creatorcontrib>Hasani, Mohammad</creatorcontrib><creatorcontrib>Foroumadi, Alireza</creatorcontrib><creatorcontrib>Nadri, Hamid</creatorcontrib><creatorcontrib>Emami, Saeed</creatorcontrib><creatorcontrib>Samadi, Nasrin</creatorcontrib><creatorcontrib>Faramarzi, Mohammad Ali</creatorcontrib><creatorcontrib>Saniee, Parastoo</creatorcontrib><creatorcontrib>Siavoshi, Farideh</creatorcontrib><creatorcontrib>Abadian, Neda</creatorcontrib><creatorcontrib>Mahmoudjanlou, Yasaman</creatorcontrib><creatorcontrib>Sakhteman, Amirhossein</creatorcontrib><creatorcontrib>Moradi, Alireza</creatorcontrib><creatorcontrib>Shafiee, Abbas</creatorcontrib><title>5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents</title><title>Medicinal chemistry research</title><addtitle>Med Chem Res</addtitle><description>In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as
Helicobacter pylori
strains. Biological data indicated that 5-nitrofuran analog
5a
and 5-nitroimidazole analog
7a
containing no substitutions on the thiazole ring were the most potent compounds.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Original Research</subject><subject>Pharmacology/Toxicology</subject><issn>1054-2523</issn><issn>1554-8120</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kNtKAzEQhoMoWKsP4N2-QHSSTTbppRRPUPRGr0M2O2lTtokkq6BPb2r1VhiY4__DfIRcMrhiAOq6AIAQFBinwLmg3RGZMSkF1YzDca2h1lzy9pSclbIFaBUIOSNJ0qcw5UQ3OGFONn-OYcCIjY12TOvSJN9wOm2C_Upj3e1CTFT8DcJQ24ilsTWamD5wbArmgD86G6fQW1d9gx0bu8Y4lXNy4u1Y8OI3z8nr3e3L8oGunu8flzcr6rjWE9WLVjNU2oP2coE9a9nQSee1VZJp33eMOyE5906jVeisUr2HFrmUAwfr2jlhB1-XUykZvXnLYVffMwzMnpg5EDOVmNkTM13V8IOm1Nu4xmy26T1XDuUf0TcsIHBk</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Hosseinzadeh, Nouraddin</creator><creator>Hasani, Mohammad</creator><creator>Foroumadi, Alireza</creator><creator>Nadri, Hamid</creator><creator>Emami, Saeed</creator><creator>Samadi, Nasrin</creator><creator>Faramarzi, Mohammad Ali</creator><creator>Saniee, Parastoo</creator><creator>Siavoshi, Farideh</creator><creator>Abadian, Neda</creator><creator>Mahmoudjanlou, Yasaman</creator><creator>Sakhteman, Amirhossein</creator><creator>Moradi, Alireza</creator><creator>Shafiee, Abbas</creator><general>Springer-Verlag</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20130501</creationdate><title>5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents</title><author>Hosseinzadeh, Nouraddin ; Hasani, Mohammad ; Foroumadi, Alireza ; Nadri, Hamid ; Emami, Saeed ; Samadi, Nasrin ; Faramarzi, Mohammad Ali ; Saniee, Parastoo ; Siavoshi, Farideh ; Abadian, Neda ; Mahmoudjanlou, Yasaman ; Sakhteman, Amirhossein ; Moradi, Alireza ; Shafiee, Abbas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-89381e78f08f59eb131d65cf8a7518fb612c4522fc8ea7eca77bf03e255d20ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Original Research</topic><topic>Pharmacology/Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosseinzadeh, Nouraddin</creatorcontrib><creatorcontrib>Hasani, Mohammad</creatorcontrib><creatorcontrib>Foroumadi, Alireza</creatorcontrib><creatorcontrib>Nadri, Hamid</creatorcontrib><creatorcontrib>Emami, Saeed</creatorcontrib><creatorcontrib>Samadi, Nasrin</creatorcontrib><creatorcontrib>Faramarzi, Mohammad Ali</creatorcontrib><creatorcontrib>Saniee, Parastoo</creatorcontrib><creatorcontrib>Siavoshi, Farideh</creatorcontrib><creatorcontrib>Abadian, Neda</creatorcontrib><creatorcontrib>Mahmoudjanlou, Yasaman</creatorcontrib><creatorcontrib>Sakhteman, Amirhossein</creatorcontrib><creatorcontrib>Moradi, Alireza</creatorcontrib><creatorcontrib>Shafiee, Abbas</creatorcontrib><collection>CrossRef</collection><jtitle>Medicinal chemistry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosseinzadeh, Nouraddin</au><au>Hasani, Mohammad</au><au>Foroumadi, Alireza</au><au>Nadri, Hamid</au><au>Emami, Saeed</au><au>Samadi, Nasrin</au><au>Faramarzi, Mohammad Ali</au><au>Saniee, Parastoo</au><au>Siavoshi, Farideh</au><au>Abadian, Neda</au><au>Mahmoudjanlou, Yasaman</au><au>Sakhteman, Amirhossein</au><au>Moradi, Alireza</au><au>Shafiee, Abbas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents</atitle><jtitle>Medicinal chemistry research</jtitle><stitle>Med Chem Res</stitle><date>2013-05-01</date><risdate>2013</risdate><volume>22</volume><issue>5</issue><spage>2293</spage><epage>2302</epage><pages>2293-2302</pages><issn>1054-2523</issn><eissn>1554-8120</eissn><abstract>In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as
Helicobacter pylori
strains. Biological data indicated that 5-nitrofuran analog
5a
and 5-nitroimidazole analog
7a
containing no substitutions on the thiazole ring were the most potent compounds.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><doi>10.1007/s00044-012-0224-6</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1054-2523 |
| ispartof | Medicinal chemistry research, 2013-05, Vol.22 (5), p.2293-2302 |
| issn | 1054-2523 1554-8120 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_s00044_012_0224_6 |
| source | Springer Nature |
| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Original Research Pharmacology/Toxicology |
| title | 5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents |
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