Synthesis of some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives incorporating aminothiazole moiety and investigation of their antioxidant, acetylcholinesterase, and butyrylcholinesterase inhibitory activities

In this study, 12 new compounds were synthesized, six of which were 3(2 H )-pyridazinone ( 9a – f ) and the others were 1(2 H )-phthalazinone ( 10a–f ) derivatives. The chemical structures of new compounds were confirmed by 1 H-NMR, 13 C-NMR, mass, and elemental analysis. The antioxidant properties...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2015-03, Vol.24 (3), p.1210-1217
Main Authors: Yamalı, Cem, Ozan Gülcan, H., Kahya, Burcu, Çobanoğlu, Simla, Kadir Şüküroğlu, M., Doğruer, Deniz S.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, 12 new compounds were synthesized, six of which were 3(2 H )-pyridazinone ( 9a – f ) and the others were 1(2 H )-phthalazinone ( 10a–f ) derivatives. The chemical structures of new compounds were confirmed by 1 H-NMR, 13 C-NMR, mass, and elemental analysis. The antioxidant properties of all the synthesized compounds were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide radical scavenging assays. Moreover, cholinesterase inhibitory profiles of the synthesized compounds were determined using an in vitro assay based on a modified version of the Ellman protocol. Almost all the synthesized compounds displayed promising antioxidant activity, particularly in the DPPH radical scavenging assay, however, their inhibitory activities on cholinesterase enzymes pointed out structure specific interactions .
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-014-1205-8