High-fat Fructose diet induces neuroinflammation and anxiety-like behaviors by modulating liver-brain axis communication

Rationale Patients with non-alcoholic fatty liver disease (NAFLD) may experience non-cognitive impairments such as anxiety and depression. However, the specific mechanism of the association between liver injury and neurological disorders is unclear. Objectives In this study, we aimed to explore the...

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Bibliographic Details
Published in:Psychopharmacology 2025-12, Vol.242 (12), p.2651-2664
Main Authors: Du, Hongmei, Zhou, Yuan, Wang, Jia, Bai, Xianbing, Tao, Borui, Chen, Ming
Format: Article
Language:English
Subjects:
Animals
Anxiety
Anxiety - drug therapy
Anxiety - etiology
Anxiety disorders
Apoptosis
Behavior
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Brain - drug effects
Brain - metabolism
Diet, High-Fat - adverse effects
Disease Models, Animal
Enzyme-linked immunosorbent assay
Experiments
Fatty liver
Fibrosis
Fructose
Fructose - administration & dosage
Fructose - adverse effects
Glutamic Acid - metabolism
High fat diet
Hippocampus
Hydrolyzable Tannins - pharmacology
Immunofluorescence
Inflammation
Laboratory animals
Lipids
Liver
Liver - drug effects
Liver - metabolism
Liver - pathology
Liver diseases
Male
Mental depression
Metabolism
Mice
Mice, Inbred C57BL
Nervous system
Neuroinflammatory Diseases - etiology
Neurological diseases
Neurosciences
Non-alcoholic Fatty Liver Disease
Original Investigation
Oxidative stress
Pharmacology/Toxicology
Psychiatry
Tumor necrosis factor-α
Citations: Items that this one cites
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