The Effect of Melatonin on TNBS-Induced Colitis

Ulcerative colitis is a multifactorial inflammatory disease of the colon and rectum with an unknown etiology. The present study was undertaken to investigate the effect of melatonin administration on oxidative damage and apoptosis in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Rats w...

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Bibliographic Details
Published in:Digestive diseases and sciences 2006-09, Vol.51 (9), p.1538-1545
Main Authors: Necefli, Ahmet, Tulumoğlu, Burcu, Giriş, Murat, Barbaros, Umut, Gündüz, Mücteba, Olgaç, Vakur, Güloğlu, Recep, Toker, Gülçin
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Antioxidants - therapeutic use
Apoptosis - drug effects
Biological and medical sciences
Caspase 3
Caspases - metabolism
Colitis - chemically induced
Colitis - drug therapy
Colitis - metabolism
Colon - drug effects
Colon - pathology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Glutathione - metabolism
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Male
Malondialdehyde - metabolism
Melatonin - therapeutic use
Peroxidase - metabolism
Rats
Rats, Wistar
Trinitrobenzenesulfonic Acid - toxicity
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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